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英文名：[(3R)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;2,2,2-trifluoroacetic acid
品牌：BroadPharm
规格：1 MG、5 MG
产品说明：CAS No. 909725-62-8；脂质体及LNP的合成脂质材料；鞘脂
产地：美国
包装容器：西林瓶/塑料瓶
无菌处理：/
保存条件：零下20°C
保质期限：详见产品包装
| 产品信息 | |
| 产品名称 (Product Name) | W146 |
| CAS 号 (CAS No.) | 909725-62-8 |
| 分子式 (Formula) | C16H27N2O4P |
| 分子量 (Molecular Weight) | 342.4 |
| SMILES | CCCCCCC1=CC(=CC=C1)NC(=O)C(CCP(=O)(O)O)N.C(=O)(C(F)(F)F)O |
| 运输条件 (Shipping) | Ambient Temperature |
| 储存方式 (Storage) | -20°C |
| 产品分类 (Category) | 脂质;鞘脂 |
| 生物活性：W146 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (Ki = 77 nM).1 It is selective for S1P1 over S1P2, S1P3, and S1P5 receptors (Kis = >10 µM for all). W146 prevents ligand-induced receptor internalization in CHO cells and inhibits the phosphorylation of ERK1 and Akt when used at a concentration of 10 µM. W146 (5 mg/kg) increases AMD3100-induced Kit+/Sca-1+/Lin− hematopoietic stem progenitor cell (KSL-HSPC) entrance into mouse blood circulation from the bone marrow when administered in combination with the chemokine (C-X-C motif) receptor 4 (CXCR4) antagonist and stem cell-mobilizer AMD3100.2 Intranasal or intradermal administration of W146 (10 µg) also disrupts the endothelial barrier and induces the infiltration of polymorphonuclear (PMN) neutrophils into the lungs and skin in an ovalbumin-induced mouse model of immune cell-mediated vascular injury. | |
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