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英文名：[(Z)-non-2-enyl] 9-[4-[2-[bis[9-[(Z)-non-2-enoxy]-9-oxononyl]amino]ethyl]piperazin-1-yl]nonanoate
品牌：BroadPharm
规格：5 MG、10 MG
产品说明：CAS No. 2956402-64-3；脂质体及LNP的合成脂质材料；支链脂质、可电离脂质
产地：美国
包装容器：西林瓶/塑料瓶
无菌处理：/
保存条件：零下20°C
保质期限：详见产品包装
| 产品信息 | |
| 产品名称 (Product Name) | 244cis (solution in ethanol) |
| 中文名称 (Chinese Name) | 244顺式 |
| CAS 号 (CAS No.) | 2956402-64-3 |
| 分子式 (Formula) | C60H111N3O6 |
| 分子量 (Molecular Weight) | 970.6 |
| 纯度 (Purity) | 99.67% |
| 性状 (Appearance) | 液体 |
| SMILES | CCCCCC/C=CCOC(=O)CCCCCCCCN1CCN(CC1)CCN(CCCCCCCCC(=O)OC/C=CCCCCCC)CCCCCCCCC(=O)OC/C=CCCCCCC |
| 运输条件 (Shipping) | Ambient Temperature |
| 储存方式 (Storage) | -20°C |
| 产品分类 (Category) | 脂质;支链脂质、可电离脂质 |
| 生物活性：244cis is an ionizable cationic lipid (pKa = 6.3) utilized in the development of lipid nanoparticles (LNPs). In mice, LNPs containing 244cis and an mRNA reporter preferentially accumulate in the lungs and result in lower serum chemokine (C-C motif) ligand 2 (Ccl2) levels compared to LNPs with SM-102. Intravenous administration of 244cis-based LNPs encapsulating mRNA encoding Cre recombinase increases tdTomato fluorescence in lung endothelial, epithelial, and immune cells, as well as fibroblasts, in mice engineered with a floxed STOP codon to prevent tdTomato expression. Furthermore, LNPs with 244cis and siRNA targeting G2 and S-phase expressed 1 (Gtse1) reduce hepatic fibrosis, decrease Il-6 and Tnf-α production, and lower alanine transaminase (ALT) and aspartate aminotransferase (AST) levels compared to SM-102-based LNPs in a mouse model of carbon tetrachloride-induced liver injury. | |
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